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In this case, the enzyme -glutamylcyclotransferase catalyzes the conversion of -glutamyl-L-cysteine to 5-oxoproline, favoring the occurrence of 5-oxoprolinuria, chronic metabolic acidosis and neurological disorders (Figure 2) [22]

Cerebrolysin demonstrates superior performance in acute ischemic stroke models, with Phase IV clinical trials showing measurable cognitive improvements at 30ml daily IV for 21 days in post-stroke patients, and rodent MCAO (middle cerebral artery occlusion) studies documenting 1825% reductions in infarct volume

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